P094 WHICH 5-ASA? VARIATION IN COLONIC MUCOSAL CONCENTRATION OF DIFFERENT PHARMACEUTICAL MESALAMINE FORMULATIONS

Release of 5-Aminosalicylic Acid (5-ASA) from Mesalamine Formulations at Various pH Levels

INTRODUCTION Oral formulations of 5-aminosalicylic acid (5-ASA) for treatment of ulcerative colitis have been developed to minimize absorption prior to the drug reaching the colon. In this study, we investigate the release of 5-ASA from available oral mesalamine formulations in physiologically relevant pH conditions. METHODS Release of 5-ASA from 6 mesalamine formulations (APRISO®, Salix Phar...

Which 5-ASA?

When Asacol commands 65% of the UK market, can so many British gastroenterologists be wrong? Possibly. The market leader in France is Pentasa (72%) and is Salofalk in Germany (57%). In Canada it is Asacol (46%). Nevertheless, a Cochrane review of 11 trials involving 1598 patients showed that sulphasalazine was more effective than other 5-aminosalicylic acid (5-ASA) drugs for maintaining remissi...

Novel Formulations and Dosing Strategies for 5-ASA

Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation.

The effect of 5-ASA and 4-ASA, drugs used for the treatment of inflammatory bowel disease, on modulation of experimental colitis and on colonic generation of interleukin-1 was evaluated. Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat...

Ethno-pharmaceutical formulations in Kurdish ethno medicine

Abstract Kermanshah is a city in west of Iran with a specific customs and cultures between the Kermanshah is a city in west of Iran with a specific customs and cultures between the people who are living here. According to historical documents these cultures are very ancient and belong to more than one thousand years. The climate condition in this place forces people to find the solution of thei...